Toxicological profile for 1,1,2,2-tetrachloroethane

Toxicological profile for 1,1,2,2-tetrachloroethane Download PDF EPUB FB2

The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here. Each peer-reviewed profile identifies and reviews the key literature that describes a hazardous substance's toxicologic properties.

Other pertinent literature is also presented, but is described in less detail than the key studies. 1,1,2,2-TETRACHLOROETHANE iii UPDATE STATEMENT A Toxicological Profile for 1,1,2,2- tetrachloroethane, Draft for Public Comment, was released in September This edition supersedes any previously released draft or final profile.

Toxicological profiles are revised and republished as necessary. For information regarding the update. Get this from a library. Toxicological profile for 1,1,2,2-tetrachloroethane. [Syracuse Research Corporation.; Clement Associates.; United States.

Environmental. Toxicological profile for 1,1,2,2-tetrachloroethane. [Atlanta, GA]: U.S. Dept. of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, (OCoLC) TOXICOLOGICAL REVIEW.

OF 1,1,2,2-TETRACHLOROETHANE (CAS No. ) In Support of Summary Information on the. Integrated Risk Information System (IRIS) September U.S. Environmental Protection Agency Washington, DC.

1,1,2,2-Tetrachloroethane is a chlorinated derivative of has the highest solvent power of any chlorinated hydrocarbon. As a refrigerant, it is used under the name RChemical formula: C₂H₂Cl₄.

CAS number: NIOSH REL: 1 ppm (7 mg/m3) TWA [skin]; NIOSH considers 1,1,2,2-tetrachloroethane to be a potential occupational carcinogen as defined by the OSHA carcinogen policy Toxicological profile for 1,1,2,2-tetrachloroethane book CFR ].

Current OSHA PEL: 5 ppm (35 mg/m3) TWA [skin] OSHA PEL: 1 ppm (7 mg/m3) TWA [skin] ACGIH TLV: 1 ppm ( mg/m3) TWA [skin] Description of substance:. Substances and Disease Registry's (ATSDR's) Toxicological Profile for 1,1,2,2-Tetrachloroethane.

(1) Uses The production of 1,1,2,2-tetrachloroethane as an end-product has decreased significantly in the United States. (1) In the past, 1,1,2,2-tetrachloroethane was used in. contents - toxicological review of 1,1,2,2-tetrachloroethane (cas no.

) list of tables vi list of figures ix list of abbreviations and acronyms x foreword xii authors, contributors, and reviewers xiii 1. introduction 1 2. chemical and physical information 3 3. toxicokinetics 5 Very few data are available on the effects of exposure to 1,1,2,2-tetrachloroethane in humans.

The toxicological profile of 1,1,2,2-tetrachloroethane has also not been well characterized; because of the chemical's declining use, available data are confined primarily to early limited studies. Aug IRIS Toxicological Review of 1,1,2,2-Tetrachloroethane (Interagency Science Discussion Draft) (Report) Sep IRIS Toxicological Review of 1,1,2,2-Tetrachloroethane (External Review Draft) (Report) Sep Health Effects Assessment for 1,1,2,2-Tetrachloroethane (Report).

Use. In the past, 1,1,2,2-tetrachloroethane was used as a solvent, for degreasing metals, in paint removers, varnishes, lacquers, photographic film, rust removers, resins and waxes, extraction of oils and fats, and as an alcohol denaturant, in organic synthesis (Lewis, ).It has also been used in the manufacture of cyanogen chloride, polymers, and tetrachloro-alkylphenol, and as a.

In the presence of oxygen NADPH and rat liver microsomes, 1,1,1,2-tetrachloroethane undergoes little dechlorination. In contrast, NADPH-dependent reductive metabolism of 1,1,1,2-tetrachloroethane by hepatic microsomal fractions from rats yields 1,1,-dichloroethylene as the major metabolite.

"A Toxicological Profile for 1,1,2,2-tetrachloroethane, Draft for Public Comment was released in September This edition supersedes any previously released draft or final profile"--P. by: 4.

1,1,2,2-Tetrachloroethane is a manufactured, colorless, dense liquid that does not burn easily. It is volatile and has a sweet odor.

In the past, it was used in large amounts to produce other chemicals, as an industrial solvent to clean and degrease metals, and as an ingredient in paints and pesticides. Toxicological profile for 1,1,2,2-tetrachloroethane Personal Author: Smith, Lester "This toxicological profile is prepared in accordance with guidelines developed by ATSDR and EPA." Includes bibliographical references (p.

Cited by: 1. The standard is based on the biologic effects of exposure, environmental data and engineering controls, previous standards, and work practices.

Appendices are included on sampling methods, analytical methods, material safety data sheet, and the physical and chemical properties of 1,1,2,2-tetrachloroethane." - NIOSHTIC 1,1,2,2-TETRACHLOROETHANE may be incompatible with strong oxidizing and reducing agents.

Also may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides. Decomposed by heat and UV light, forming phosgene and HCl; reacts violently with finely dispersed metals [Handling Chemicals Safely p.

1,1,2,2-Tetrachloroethane is not known to occur naturally (IARC, as cited in ATSDR, ). At room temperature it is a dense, colorless liquid with a pungent, sweet, suffocating, chloroform-like smell. It is produced by the catalytic addition of chlorine toFile Size: KB.

Prepared by Research Triangle Institute under contract no. for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry"This toxicological profile is prepared in accordance with Author: H. Dewing, R.

Schluter. Tetrachloroethane, either of two isomeric colourless, dense, water-insoluble liquids belonging to the family of organic halogen isomer, 1,1,2,2-tetrachloroethane, also called acetylene tetrachloride, is highly the entire production of the compound is consumed in manufacturing chlorinated solvents, especially trichloroethylene and tetrachloroethylene; it has minor.Toxicological profile for 1,1,2,2-tetrachloroethane.

U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). Wikipedia.

1,1,2,2-Tetrachloroethane. Last Updated 7 August International Programme on Chemical Safety (IPCS) INCHEM (). Poison Information Monograph for 1,1,2,ion Number: T3DThis addendum is a non-peer–reviewed supplement containing scientific data that were published in the open peer-reviewed literature since the release of the toxicological profile in Chapter numbers in this addendum coincide with the Toxicological Profile for Chloroethane ().

This document should be used in conjunction with the profile.